Injectable sustainable andrographolide-releasing hydrogel for long-lasting alleviation of osteoarthritis and regulation of chondrocyte autophagy via PRKCA/EGFR

Injectable sustainable andrographolide-releasing hydrogel for long-lasting alleviation of osteoarthritis and regulation of chondrocyte autophagy via PRKCA/EGFR

Osteoarthritis is one of the most prevalent age-related joint diseases, with chondrocyte inflammation and autophagy dysregulation serving as pivotal pathogenesis factors. Andrographolide (AD), a phytochemical identified in Andrographis paniculata, exhibits anti-inflammatory properties and regulates...

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Bibliographic Details
Main Authors: Yang Chen, Peipei He, Siyi Tao, Jintao Zhong, Kai Jiang, Yuching Hsu, Guang Xia, Xinzhan Mao, Hongxun Sang, Ke Lu
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Materials Today Bio
Subjects:
Hydrogel
Andrographolide
Autophagy
Osteoarthritis
Micelle
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425001681

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http://www.sciencedirect.com/science/article/pii/S2590006425001681

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