Respiratory Syncytial Virus Exacerbates Kidney Damages in IgA Nephropathy Mice via the C5a-C5aR1 Axis Orchestrating Th17 Cell Responses

Respiratory Syncytial Virus Exacerbates Kidney Damages in IgA Nephropathy Mice via the C5a-C5aR1 Axis Orchestrating Th17 Cell Responses

Respiratory viral infections can directly lead to kidney damage such as IgA nephropathy (IgAN), partly due to mucosal immune system dysfunction. Although the activated C5a-C5aR1 axis results in increased Th1 and Th17 frequencies but reduced Treg frequencies in Respiratory syncytial virus (RSV) infec...

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Bibliographic Details
Main Authors: Xinyue Hu, Juntao Feng, Qiaoling Zhou, Lisha Luo, Ting Meng, Yong Zhong, Wei Tang, Shuanglinzi Deng, Xiaozhao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
RSV
C5a-C5aR1 axis
IgA nephropathy exacerbation
CD4+ T cells
human mesangial cells
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00151/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2019.00151/full

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