Mechanism of cargo-directed Atg8 conjugation during selective autophagy

Mechanism of cargo-directed Atg8 conjugation during selective autophagy

Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is coupled to the presence of the cargo is unclear. He...

Full description

Bibliographic Details
Main Authors: Dorotea Fracchiolla, Justyna Sawa-Makarska, Bettina Zens, Anita de Ruiter, Gabriele Zaffagnini, Andrea Brezovich, Julia Romanov, Kathrin Runggatscher, Claudine Kraft, Bojan Zagrovic, Sascha Martens
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
selective autophagy
protein conjugation
cargo receptor
biochemical reconstitution
membrane biology
Online Access:https://elifesciences.org/articles/18544

Internet

https://elifesciences.org/articles/18544

Similar Items