HLA class, calcineurin inhibitor levels, and the risk of graft failure in kidney recipients with de novo donor-specific antibodies

HLA class, calcineurin inhibitor levels, and the risk of graft failure in kidney recipients with de novo donor-specific antibodies

IntroductionDe novo donor-specific HLA antibody (dnDSA) are associated with poor outcomes. Whether this observation applies to both HLA class I and II dnDSA remains unclear.MethodsWe studied 1236 consecutive kidney recipients who had routine anti-HLA antibody surveillance post-transplant.ResultsDuri...

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Bibliographic Details
Main Authors: Marc-Antoine Béland, Isabelle Lapointe, Isabelle Côté, Julie Lesage, Isabelle Houde, Eric Wagner, Julie Riopel, Eva Latulippe, Olivier Désy, Sacha A. De Serres
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
donor-specific alloantibodies
kidney transplantation
anti-HLA alloantibodies
graft loss
HLA class 1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493878/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493878/full

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