Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include vascular rarefaction and geographic atrophy. By cha...

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Bibliographic Details
Main Authors: Ross O Smith, Takeshi Ninchoji, Emma Gordon, Helder André, Elisabetta Dejana, Dietmar Vestweber, Anders Kvanta, Lena Claesson-Welsh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
vascular permeability
vascular endothelial growth factor receptor
macular edema
neovascularization
Online Access:https://elifesciences.org/articles/54056

Internet

https://elifesciences.org/articles/54056

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