Fluoride exposure induces lysosomal dysfunction unveiled by an integrated transcriptomic and metabolomic study in bone marrow mesenchymal stem cells

Fluoride exposure induces lysosomal dysfunction unveiled by an integrated transcriptomic and metabolomic study in bone marrow mesenchymal stem cells

Fluoride has received much attention for its predominant bone toxicity in the human body. However, the toxic mechanism of bone injury caused by fluoride exposure remains largely unclear. Bone marrow mesenchymal stem cells (BMSCs) are widely used as model cells for evaluating bone toxicity after envi...

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Bibliographic Details
Main Authors: Hui Wang, Lu Yang, Peng Gao, Ping Deng, Yang Yue, Li Tian, Jia Xie, Mengyan Chen, Yan Luo, Yidan Liang, Weijia Qing, Zhou Zhou, Huifeng Pi, Zhengping Yu
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Fluoride
Bone marrow mesenchymal stem cells
Lysosome
Transcriptomic
Metabolomic
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322005127

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http://www.sciencedirect.com/science/article/pii/S0147651322005127

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