Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue

Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue

Robust human immune system (HIS) mice are created using human fetal thymus tissue and hematopoietic stem cells (HSCs). A HIS mouse model using neonatal human thymus tissue and umbilical cord blood (CB) HSCs (NeoHu) was recently described. We improved the model by removing the native murine thymus, w...

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Bibliographic Details
Main Authors: Tara Talaie, Hui Wang, Wan-I Kuo, Nichole Danzl, Mert R. Gulsen, Amber N. Wolabaugh, Xiaolan Ding, Megan Sykes, Hao Wei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
human immune system mouse model
neonatal thymus
cord blood CD34 + cells
thymopoiesis
autoimmune disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1159341/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1159341/full

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