Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo

Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo

Abstract Background Plasmodium falciparum M1 family aminopeptidase is currently considered as a promising target for anti-malarial chemotherapy. Several series of inhibitors developed by various research groups display IC50/Ki values down to nM range on native PfA-M1 or recombinant forms and block t...

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Bibliographic Details
Main Authors: Lotfi Bounaadja, Marjorie Schmitt, Sébastien Albrecht, Elisabeth Mouray, Céline Tarnus, Isabelle Florent
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
M1 aminopeptidase
Chemotherapy
Amino-benzosuberone derivative
Online Access:http://link.springer.com/article/10.1186/s12936-017-2032-4

Internet

http://link.springer.com/article/10.1186/s12936-017-2032-4

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