In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development

In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development

How pancreatic β-cells acquire function in vivo is a long-standing mystery due to the lack of technology to visualize β-cell function in living animals. Here, we applied a high-resolution two-photon light-sheet microscope for the first in vivo imaging of Ca2+activity of every β-cell in Tg (ins:Rcamp...

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Bibliographic Details
Main Authors: Jia Zhao, Weijian Zong, Yiwen Zhao, Dongzhou Gou, Shenghui Liang, Jiayu Shen, Yi Wu, Xuan Zheng, Runlong Wu, Xu Wang, Fuzeng Niu, Aimin Wang, Yunfeng Zhang, Jing-Wei Xiong, Liangyi Chen, Yanmei Liu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
functionality of β-cells in vivo
ins:Rcamp1.07 zebrafish
2P3A-DSLM
microcirculation
glucose
Calcineurin/NFAT
Online Access:https://elifesciences.org/articles/41540

Internet

https://elifesciences.org/articles/41540

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