An Efficient Approach to 2-CF<sub>3</sub>-Indoles Based on <i>ortho</i>-Nitrobenzaldehydes

An Efficient Approach to 2-CF<sub>3</sub>-Indoles Based on <i>ortho</i>-Nitrobenzaldehydes

The catalytic olefination reaction of 2-nitrobenzaldehydes with CF<sub>3</sub>CCl<sub>3</sub> afforded stereoselectively trifluoromethylated <i>ortho</i>-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF&l...

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Bibliographic Details
Main Authors: Vasiliy M. Muzalevskiy, Zoia A. Sizova, Vladimir T. Abaev, Valentine G. Nenajdenko
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
CF<sub>3</sub>-group
catalytic olefination reaction
nitro group
reduction
indole
fluorine
Online Access:https://www.mdpi.com/1420-3049/26/23/7365

Internet

https://www.mdpi.com/1420-3049/26/23/7365

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