Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80.

Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80.

Meiotic recombination plays a critical role in sexual reproduction by creating crossovers between homologous chromosomes. These crossovers, along with sister chromatid cohesion, connect homologs to enable proper segregation at Meiosis I. Recombination is initiated by programmed double strand breaks...

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Bibliographic Details
Main Authors: Xiangyu Chen, Robert Gaglione, Trevor Leong, Lauren Bednor, Teresa de Los Santos, Ed Luk, Michael Airola, Nancy M Hollingsworth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007832

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https://doi.org/10.1371/journal.pgen.1007832

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