Anticholinesterase activity of β-carboline-1,3,5-triazine hybrids

Anticholinesterase activity of β-carboline-1,3,5-triazine hybrids

Abstract The β-carboline-1,3,5-triazine hydrochlorides 8-13 were evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The analysed compounds were selective to BuChE, with IC50 values in the range from 1.0-18.8 µM being obtained. The N-{2-[(4,6-dihydrazinyl-1,3,5-...

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Bibliographic Details
Main Authors: Paula Baréa, Valéria Aquilino Barbosa, Diego Alberto dos Santos Yamazaki, Carla Maria Beraldi Gomes, Claudio R. Novello, Willian Ferreira da Costa, Gisele de Freitas Gauze, Maria Helena Sarragiotto
Format: Article
Language:English
Published: Universidade de São Paulo 2022-07-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
β-carboline. 1,3,5-triazine. Acetylcholinesterase. Butyrylcholinesterase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100650&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100650&tlng=en

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