Rapid Identification of New Biomarkers for the Classification of GM1 Type 2 Gangliosidosis Using an Unbiased <sup>1</sup>H NMR-Linked Metabolomics Strategy

Rapid Identification of New Biomarkers for the Classification of GM1 Type 2 Gangliosidosis Using an Unbiased <sup>1</sup>H NMR-Linked Metabolomics Strategy

Biomarkers currently available for the diagnosis, prognosis, and therapeutic monitoring of GM1 gangliosidosis type 2 (GM1T2) disease are mainly limited to those discovered in targeted proteomic-based studies. In order to identify and establish new, predominantly low-molecular-mass biomarkers for thi...

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Bibliographic Details
Main Authors: Benita C. Percival, Yvonne L. Latour, Cynthia J. Tifft, Martin Grootveld
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
GM1 gangliosidosis
lysosomal storage disorders
nuclear magnetic resonance (NMR) analysis
NMR-based metabolomics
biomarkers
validation
Online Access:https://www.mdpi.com/2073-4409/10/3/572

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https://www.mdpi.com/2073-4409/10/3/572

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