Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

Metformin-induced activation of Ca2+ signaling prevents immune infiltration/pathology in Sjogren’s syndrome-prone mouse models

Immune cell infiltration and glandular dysfunction are the hallmarks of autoimmune diseases such as primary Sjogren’s syndrome (pSS), however, the mechanism(s) is unknown. Our data show that metformin-treatment induces Ca2+ signaling that restores saliva secretion and prevents immune cell infiltrati...

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Bibliographic Details
Main Authors: Viviane Nascimento Da Conceicao, Yuyang Sun, Xiufang Chai, Julian L. Ambrus, Bibhuti B. Mishra, Brij B. Singh
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Translational Autoimmunity
Subjects:
Primary Sjogren’s syndrome
Ca2+ signaling
Metformin, immune cell activation
ER stress
Alarmins
Salivary gland dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909023000230

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http://www.sciencedirect.com/science/article/pii/S2589909023000230

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