Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing

Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing

Single-cell RNA-sequencing (scRNA-seq) presents better insights into cell behavior in the context of a complex tumor microenvironment by profiling single-cell populations. However, the mechanisms underlying treatment failure in hepatocellular carcinoma (HCC) are poorly understood. In this study, we...

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Bibliographic Details
Main Authors: Xiaopei Hao, Zhiying Zheng, Hanyuan Liu, Yao Zhang, Junwei Kang, Xiangyi Kong, Dawei Rong, Guangshun Sun, Guoqiang Sun, Li Liu, Haibo Yu, Weiwei Tang, Xuehao Wang
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Redox Biology
Subjects:
APOC1
Hepatocellular carcinoma
Single-cell RNA sequencing
Ferroptosis
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172200235X

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http://www.sciencedirect.com/science/article/pii/S221323172200235X

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