Genetic and pharmacological relationship between P-glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An epidemiological and genomic population-based cohort study in Scotland, UK.

Genetic and pharmacological relationship between P-glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An epidemiological and genomic population-based cohort study in Scotland, UK.

<h4>Background</h4>There are conflicting reports regarding the association of the macrolide antibiotic clarithromycin with cardiovascular (CV) events. A possible explanation may be that this risk is partly mediated through drug-drug interactions and only evident in at-risk populations. T...

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Bibliographic Details
Main Authors: Ify R Mordi, Benjamin K Chan, N David Yanez, Colin N A Palmer, Chim C Lang, James D Chalmers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1003372

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https://doi.org/10.1371/journal.pmed.1003372

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