Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance

Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance

Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) catalyze the rate-limiting step of tryptophan catabolism along the kynurenine pathway, which has important immuno suppressive properties, particularly in tumor cells and dendritic cells. The prominent expression of IDO1 in the...

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Bibliographic Details
Main Authors: Delia Hoffmann, Tereza Dvorakova, Florence Schramme, Vincent Stroobant, Benoit J. Van den Eynde
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
placenta
decidual stromal cell
immunohistochemistry
feto-maternal tolerance
TDO - tryptophan 2,3-dioxygenase
IDO1—indoleamine 2,3-dioxygenase 1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.601759/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.601759/full

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