A Study of a Protein-Folding Machine: Transient Rotation of the Polypeptide Backbone Facilitates Rapid Folding of Protein Domains in All-Atom Molecular Dynamics Simulations

A Study of a Protein-Folding Machine: Transient Rotation of the Polypeptide Backbone Facilitates Rapid Folding of Protein Domains in All-Atom Molecular Dynamics Simulations

Molecular dynamics simulations of protein folding typically consider the polypeptide chain at equilibrium and in isolation from the cellular components. We argue that in order to understand protein folding as it occurs in vivo, it should be modeled as an active, energy-dependent process, in which th...

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Bibliographic Details
Main Authors: Harutyun Sahakyan, Karen Nazaryan, Arcady Mushegian, Irina Sorokina
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
protein folding
ribosome function
molecular dynamics
energy-dependent protein folding
co-translational protein folding
nascent peptide rotation
Online Access:https://www.mdpi.com/1422-0067/24/12/10049

Internet

https://www.mdpi.com/1422-0067/24/12/10049

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