Elongator promotes neuritogenesis via regulation of tau stability through acly activity

Elongator promotes neuritogenesis via regulation of tau stability through acly activity

The six subunits (Elp1 to Elp6) Elongator complex promotes specific uridine modifications in tRNA’s wobble site. Moreover, this complex has been indirectly involved in the regulation of α-tubulin acetylation in microtubules (MTs) via the stabilization of ATP-Citrate Lyase (Acly), the main cytosolic...

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Bibliographic Details
Main Authors: Michal Shilian, Aviel Even, Hila Gast, Laurent Nguyen, Miguel Weil
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
elongator complex
MAPT/Tau protein
neuritogenesis
protein acetylation
familial dysautonomia
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1015125/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1015125/full

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