Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

We describe a simple bioinformatics method for biomarker discovery that is based on the analysis of global transcript levels in a population of inbred mouse strains showing variation for disease-related traits. This method has advantages such as controlled environment and accessibility to heart and...

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Bibliographic Details
Main Authors: Liang-Yu Lin, Sunny Chun Chang, Jim O’Hearn, Simon T. Hui, Marcus Seldin, Pritha Gupta, Galyna Bondar, Mario Deng, Raimo Jauhiainen, Johanna Kuusisto, Markku Laakso, Janet S. Sinsheimer, Arjun Deb, Christoph Rau, Shuxun Ren, Yibin Wang, Aldons J. Lusis, Jessica J. Wang, Adriana Huertas-Vazquez
Format: Article
Language:English
Published: Oxford University Press 2018-11-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Biomarkers, GPNMB
Heart failure
Systems genetics, Transcriptome
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200655

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200655

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