Wise regulates bone deposition through genetic interactions with Lrp5.

Wise regulates bone deposition through genetic interactions with Lrp5.

In this study using genetic approaches in mouse we demonstrate that the secreted protein Wise plays essential roles in regulating early bone formation through its ability to modulate Wnt signaling via interactions with the Lrp5 co-receptor. In Wise-/- mutant mice we find an increase in the rate of o...

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Bibliographic Details
Main Authors: Debra L Ellies, Androulla Economou, Beth Viviano, Jean-Philippe Rey, Stephenie Paine-Saunders, Robb Krumlauf, Scott Saunders
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4006890?pdf=render

Internet

http://europepmc.org/articles/PMC4006890?pdf=render

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