Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation. PTX3 has been shown to interact with the globular recognition domains (gC1q) of the C1q protein of the classical...

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Bibliographic Details
Main Authors: Isabelle Bally, Antonio Inforzato, Fabien Dalonneau, Matteo Stravalaci, Barbara Bottazzi, Christine Gaboriaud, Nicole M. Thielens
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
complement C1q
PTX3
IgM
site-directed mutagenesis
molecular interactions
complement activation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00461/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00461/full

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