Null mutation of the endothelin receptor type B gene causes embryonic death in the GK rat.

Null mutation of the endothelin receptor type B gene causes embryonic death in the GK rat.

The Hirschsprung disease (HSCR) is an inherited disease that is controlled by multiple genes and has a complicated genetic mechanism. HSCR patients suffer from various extents of constipation due to dysplasia of the enteric nervous system (ENS), which can be so severe as to cause complete intestinal...

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Main Authors: Jinxi Wang, Ruihua Dang, Yoshiki Miyasaka, Kousuke Hattori, Daisuke Torigoe, Tadashi Okamura, Hassan T Tag-Ei-Din-Hassan, Masami Morimatsu, Tomoji Mashimo, Takashi Agui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0217132

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https://doi.org/10.1371/journal.pone.0217132

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