Sericin enhances ammonia detoxification by promotes urea cycle enzyme genes and activates hepatic autophagy in relation to CARD-9/MAPK pathway

Sericin enhances ammonia detoxification by promotes urea cycle enzyme genes and activates hepatic autophagy in relation to CARD-9/MAPK pathway

Urea cycle is an important metabolic process that initiates in liver mitochondria and converts ammonia to urea. The impairment of ammonia detoxification, both primary and secondary causes, lead to hyperammonemia, a life-threatening condition affecting to the brain. Current treatments are not enough...

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Bibliographic Details
Main Authors: Sumate Ampawong, Napatara Tirawanchai, Tapanee Kanjanapruthipong, Kamonpan Fongsodsri, Khwanchanok Tuentam, Duangnate Isarangkul, Pornanong Aramwit
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Ammonia detoxification
Hepatocyte
Pathology
Sericin
Urea
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023087716

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023087716

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