Assessing target engagement using proteome-wide solvent shift assays

Assessing target engagement using proteome-wide solvent shift assays

Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increasing concentrations of organic solvents stimulate u...

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Bibliographic Details
Main Authors: Jonathan G Van Vranken, Jiaming Li, Dylan C Mitchell, José Navarrete-Perea, Steven P Gygi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
target engagement
drug discovery
mass spectrometry
proteomics
Online Access:https://elifesciences.org/articles/70784

Internet

https://elifesciences.org/articles/70784

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