CDT of <i>Clostridioides difficile</i> Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

CDT of <i>Clostridioides difficile</i> Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

Background: <i>Clostridioides difficile</i> binary toxin (CDT) defines the hypervirulence of strains in nosocomial antibiotic-induced colitis with the highest mortality. The objective of our study was to investigate the impact of CDT on the intestinal epithelial barrier and to enlighten...

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Bibliographic Details
Main Authors: Lucas Heils, Martina Schneemann, Ralf Gerhard, Jörg-Dieter Schulzke, Roland Bücker
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Toxins
Subjects:
binary toxin
tight junction
barrier function
claudin
tricellulin
occludin
Online Access:https://www.mdpi.com/2072-6651/15/1/54

Internet

https://www.mdpi.com/2072-6651/15/1/54

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