Testing preexisting antibodies prior to AAV gene transfer therapy: rationale, lessons and future considerations

Testing preexisting antibodies prior to AAV gene transfer therapy: rationale, lessons and future considerations

Given the increasing number of gene transfer therapy studies either completed or underway, there is growing attention to the importance of preexisting adaptive immunity to the viral vectors used. The recombinant viral vectors developed for gene transfer therapy share structural features with natural...

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Bibliographic Details
Main Authors: Jerry R. Mendell, Anne M. Connolly, Kelly J. Lehman, Danielle A. Griffin, Sohrab Z. Khan, Sachi D. Dharia, Lucía Quintana-Gallardo, Louise R. Rodino-Klapac
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adeno-associated virus
antibodies
assays
binding assays
efficacy
gene transfer therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000274

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http://www.sciencedirect.com/science/article/pii/S2329050122000274

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