Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs

Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs

Abstract Background Pulmonary hypertension (PH) is characterized by progressive pulmonary arterial remodelling, associated with different severities of inflammation and altered immune processes. Disulfiram eliminates the formation of N-gasdermin D (GSDMD) plasma membrane pores to prevent pyroptosis....

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Bibliographic Details
Main Authors: Shunlian Hu, Lu Wang, Yahan Xu, Fajiu Li, Tao Wang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Respiratory Research
Subjects:
Pulmonary hypertension
Pyroptosis
Disulfiram
Online Access:https://doi.org/10.1186/s12931-022-02279-0

Internet

https://doi.org/10.1186/s12931-022-02279-0

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