UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway

UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway

Ubiquitin carboxyl-terminal esterase L1 (UCHL1) has been thought to be a neuron specific protein and shown to play critical roles in Parkinson's Disease and stroke via de-ubiquiting and stabilizing key pathological proteins, such as α-synuclein. In the present study, we found that UCHL1 was sig...

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Bibliographic Details
Main Authors: Bingchuan Geng, Xiaoliang Wang, Ki Ho Park, Kyung Eun Lee, Jongsoo Kim, Peng Chen, Xinyu Zhou, Tao Tan, Chunlin Yang, Xunchang Zou, Paul M. Janssen, Lei Cao, Lei Ye, Xuejun Wang, Chuanxi Cai, Hua Zhu
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Redox Biology
Subjects:
UCHL1
Ischemic cardiac injury
HIF-1α
Deubiquitylating enzyme
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000672

Internet

http://www.sciencedirect.com/science/article/pii/S2213231722000672

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