Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region

Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable Region

In vivo clinical applications of nanobodies (VHHs) require molecules that induce minimal immunoresponse and therefore possess sequences as similar as possible to the human VH domain. Although the relative sequence variability in llama nanobodies has been used to identify scaffolds with partially hum...

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Bibliographic Details
Main Authors: Miguel A. Soler, Barbara Medagli, Jiewen Wang, Sandra Oloketuyi, Gregor Bajc, He Huang, Sara Fortuna, Ario de Marco
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomolecules
Subjects:
nanobody framework
modeling
nanobody humanization
CDR grafting
Online Access:https://www.mdpi.com/2218-273X/11/2/163

Internet

https://www.mdpi.com/2218-273X/11/2/163

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