Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

Trained immunity is the long-term functional reprogramming of innate immune cells, which results in altered responses toward a secondary challenge. Despite indoxyl sulfate (IS) being a potent stimulus associated with chronic kidney disease (CKD)-related inflammation, its impact on trained immunity h...

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Bibliographic Details
Main Authors: Hee Young Kim, Yeon Jun Kang, Dong Hyun Kim, Jiyeon Jang, Su Jeong Lee, Gwanghun Kim, Hee Byung Koh, Ye Eun Ko, Hyun Mu Shin, Hajeong Lee, Tae-Hyun Yoo, Won-Woo Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-07-01
Series:eLife
Subjects:
trained immunity
indoxyl sulfate
chronic kidney disease
aryl hydrocarbon receptor
epigenetic
metabolic reprogramming
Online Access:https://elifesciences.org/articles/87316

Internet

https://elifesciences.org/articles/87316

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