HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

Summary: By sorting receptor tyrosine kinases into endolysosomes, the endosomal sorting complexes required for transport (ESCRTs) are thought to attenuate oncogenic signaling in tumor cells. Paradoxically, ESCRT members are upregulated in tumors. Here, we show that disruption of hepatocyte growth fa...

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Bibliographic Details
Main Authors: Wei Zhang, Jiegang Yang, Beike Wang, Youtao Lu, Jingbo Yang, Wenqun Zhong, Ziyan Yu, Zhiyuan Qin, Bolin Xiao, Kuiming Wang, Yi Y. Ma, Ravi Amaravadi, Meenhard Herlyn, Junhyong Kim, Xiaowei Xu, Wei Guo
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013645

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http://www.sciencedirect.com/science/article/pii/S2211124723013645

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