Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity

Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity

We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1,2,4-triazole (compounds 3–6), 4,5-dicyanoimidazole (compound 7), and purine (compounds 8–13) coumarin derivatives and their acyclic nucleoside analogues 14–18. Structures of novel compounds 3–18 were deduced from...

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Bibliographic Details
Main Authors: Mladen Mintas, Karlo Wittine, Krešimir Pavelić, Sandra Kraljević Pavelić, Mirela Sedić, Marko Klobučar, Tomislav Suhina, Leo Mandić, Krešimir Benci
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Molecules
Subjects:
1,2,4-triazole
4,5-dicyanoimidazole and purine coumarin derivatives
acyclic nucleoside analogues
antitumor activity evaluation
Online Access:http://www.mdpi.com/1420-3049/17/9/11010

Internet

http://www.mdpi.com/1420-3049/17/9/11010

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