Cold Atmospheric Plasma Increases Temozolomide Sensitivity of Three-Dimensional Glioblastoma Spheroids via Oxidative Stress-Mediated DNA Damage

Cold Atmospheric Plasma Increases Temozolomide Sensitivity of Three-Dimensional Glioblastoma Spheroids via Oxidative Stress-Mediated DNA Damage

Glioblastoma multiforme (GBM) is the most frequent and aggressive primary malignant brain tumor in adults. Current standard radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide (TMZ) yield poor clinical outcome. This is due to the stem-like properties of tumor cells and gene...

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Bibliographic Details
Main Authors: Priyanka Shaw, Naresh Kumar, Angela Privat-Maldonado, Evelien Smits, Annemie Bogaerts
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
temozolomide
cold atmospheric plasma
glioblastoma
reactive oxygen and nitrogen species
oxidative stress
spheroid model
Online Access:https://www.mdpi.com/2072-6694/13/8/1780

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https://www.mdpi.com/2072-6694/13/8/1780

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