High-Dose Primaquine Induces Proximal Tubular Degeneration and Ventricular Cardiomyopathy Linked to Host Cells Mitochondrial Dysregulation

High-Dose Primaquine Induces Proximal Tubular Degeneration and Ventricular Cardiomyopathy Linked to Host Cells Mitochondrial Dysregulation

Primaquine (PQ) is the only antimalarial medication used to eradicate many species of <i>Plasmodium</i> gametocytes and prevent relapse in vivax and ovale malarias. PQ metabolites induce oxidative stress and impair parasitic mitochondria, leading to protozoal growth retardation and death...

Full description

Bibliographic Details
Main Authors: Atthasit Rabiablok, Borimas Hanboonkunupakarn, Khwanchanok Tuentam, Kamonpan Fongsodsri, Tapanee Kanjanapruthipong, Sumate Ampawong
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Toxics
Subjects:
heart
kidney
liver
mitochondria
primaquine
toxicity
Online Access:https://www.mdpi.com/2305-6304/11/2/146

Internet

https://www.mdpi.com/2305-6304/11/2/146

Similar Items