High-Dose Primaquine Induces Proximal Tubular Degeneration and Ventricular Cardiomyopathy Linked to Host Cells Mitochondrial Dysregulation
Primaquine (PQ) is the only antimalarial medication used to eradicate many species of <i>Plasmodium</i> gametocytes and prevent relapse in vivax and ovale malarias. PQ metabolites induce oxidative stress and impair parasitic mitochondria, leading to protozoal growth retardation and death...
Main Authors: | Atthasit Rabiablok, Borimas Hanboonkunupakarn, Khwanchanok Tuentam, Kamonpan Fongsodsri, Tapanee Kanjanapruthipong, Sumate Ampawong |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
|
Series: | Toxics |
Subjects: | |
Online Access: | https://www.mdpi.com/2305-6304/11/2/146 |
Similar Items
-
Sericin enhances ammonia detoxification by promotes urea cycle enzyme genes and activates hepatic autophagy in relation to CARD-9/MAPK pathway
by: Sumate Ampawong, et al.
Published: (2023-11-01) -
Sericin coated thin polymeric films reduce keratinocyte proliferation via the mTOR pathway and epidermal inflammation through IL17 signaling in psoriasis rat model
by: Pornanong Aramwit, et al.
Published: (2023-07-01) -
Primaquine phosphate (primaquine diphosphate)
by: 982 SIRIM -
Primaquine phosphate tablets
by: 982 SIRIM -
Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study
by: Waritda Pookmanee, et al.
Published: (2021-07-01)