<i>O</i>-Substituted <i>N</i>(3)-benzyl analogs of vitamin B<sub>1</sub> as inhibitors of acetylcholinesterase or butyrylcholinesterase

<i>O</i>-Substituted <i>N</i>(3)-benzyl analogs of vitamin B<sub>1</sub> as inhibitors of acetylcholinesterase or butyrylcholinesterase

O-Acyl substituted derivatives of 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium chloride which is a structural analog of vitamin B1 were synthesized and evaluated towards acetylcholinesterase and butyrylcholinesterase in vitro. The inhibition properties of the O-substituted compounds depend on...

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Bibliographic Details
Main Authors: Oleksandr Kobzar, Alla Ocheretniuk, Vladyslav Buldenko, Lubov Babiy, Оleksandr Kozachenko, Volodymyr Brovarets, Andriy Vovk
Format: Article
Language:English
Published: Growing Science 2020-01-01
Series:Current Chemistry Letters
Subjects:
Thiazolium salts
Acetylcholinesterase
Butyrylcholinesterase
Enzyme inhibition
Molecular docking
Online Access:http://www.growingscience.com/ccl/Vol9/ccl_2019_25.pdf

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http://www.growingscience.com/ccl/Vol9/ccl_2019_25.pdf

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