CD4+CD25+ T regulatory cells in renal transplantation

CD4+CD25+ T regulatory cells in renal transplantation

The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4+CD25+Foxp3+T regulatory cells (Treg) can down-regulate allograft rejection and can induce immune tolerance to the allograft. Treg represent <10% of peripheral CD4+T cells and do n...

Full description

Bibliographic Details
Main Authors:	Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. Spicer, Nirupama D. Verma, Suzanne J. Hodgkinson, Bruce M. Hall
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Immunology
Subjects:	kidney transplantation regulatory T cell transplant tolerance Treg transplantation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1017683/full

Similar Items

Transplant Tolerance, Not Only Clonal Deletion
by: Bruce M. Hall, et al.
Published: (2022-04-01)

Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor
by: Bruce M. Hall, et al.
Published: (2021-11-01)

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction
by: Nirupama D. Verma, et al.
Published: (2019-10-01)

Changes in Reactivity In Vitro of CD4+CD25+ and CD4+CD25− T Cell Subsets in Transplant Tolerance
by: Bruce M. Hall, et al.
Published: (2017-08-01)

Interleukin-12 (IL-12p70) promotes induction of highly potent Th1-like CD4+CD25+T regulatory cells that inhibit allograft rejection in unmodified recipients.
by: Nirupama Darshan Verma, et al.
Published: (2014-05-01)

Editorial: Regulatory T cells in immune-mediated diseases
by: Giang T. Tran, et al.
Published: (2024-12-01)

Editorial: Characterisation, functions and roles of antigen-specific regulatory T cells in health and disease
by: Giang T. Tran, et al.
Published: (2022-09-01)

ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway
by: Xiaofei Huang, et al.
Published: (2025-01-01)

Do natural Treg become activated to antigen specific Treg in transplantation and in autoimmunity?
by: Bruce Milne Hall, et al.
Published: (2013-08-01)

Multiple sclerosis patients have reduced resting and increased activated CD4+CD25+FOXP3+T regulatory cells
by: Nirupama D. Verma, et al.
Published: (2021-05-01)

CD8+CD122+PD-1+ Tregs Synergize With Costimulatory Blockade of CD40/CD154, but Not B7/CD28, to Prolong Murine Allograft Survival
by: Huazhen Liu, et al.
Published: (2019-02-01)

Herbal Components of a Novel Formula PSORI-CM02 Interdependently Suppress Allograft Rejection and Induce CD8+CD122+PD-1+ Regulatory T Cells
by: Chuanjian Lu, et al.
Published: (2018-02-01)

Blocking CD226 Promotes Allogeneic Transplant Immune Tolerance and Improves Skin Graft Survival by Increasing the Frequency of Regulatory T Cells in a Murine Model
by: Tian Liu, et al.
Published: (2018-03-01)

Metabolic Optimisation of Regulatory T Cells in Transplantation
by: Mo Atif, et al.
Published: (2020-09-01)

Cytolytic CD4+ and CD8+ Regulatory T-Cells and Implications for Developing Immunotherapies to Combat Graft-Versus-Host Disease
by: Sara Bolivar-Wagers, et al.
Published: (2022-04-01)

Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation
by: Claudia Selck, et al.
Published: (2021-05-01)

Antigen Specific Regulatory T Cells in Kidney Transplantation and Other Tolerance Settings
by: Min Hu, et al.
Published: (2021-08-01)

CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner
by: Mauricio Campos-Mora, et al.
Published: (2019-04-01)

Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity
by: Marco Romano, et al.
Published: (2019-01-01)

Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells
by: Qiaohuang Zeng, et al.
Published: (2019-04-01)

CD4+CD25+CD127-Foxp3+ and CD8+CD28- Tregs in Renal Transplant Recipients: Phenotypic Patterns, Association With Immunosuppressive Drugs, and Interaction With Effector CD8+ T Cells and CD19+IL-10+ Bregs
by: Mostafa G. Aly, et al.
Published: (2021-07-01)

Peran Penting Sel T Regulator CD8+CD25+FOXP3+ Menjaga Homeostasis Sel T pada Transplantasi Alogenik (ESSENTIAL ROLES OF CD8+CD25+FOXP3+ REGULATORY T CELLS IN THE MAINTENANCE OF T CELLS HOMEOSTASIS IN ALLOGENEIC TRANSPLANTATION)
by: Muhaimin Rifa’i, et al.
Published: (2013-12-01)

Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/− Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice
by: Séverine Bézie, et al.
Published: (2018-01-01)

The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology
by: Yasmin R. Mohseni, et al.
Published: (2020-07-01)

Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity
by: Andrzej Chruscinski, et al.
Published: (2015-07-01)

A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection
by: Feifei Qiu, et al.
Published: (2017-11-01)

Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance
by: Ji Won Han, et al.
Published: (2024-12-01)

CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications
by: Motahareh Arjomandnejad, et al.
Published: (2022-01-01)

Regulatory T-Cell Therapy in Liver Transplantation and Chronic Liver Disease
by: Angus Hann, et al.
Published: (2021-10-01)

Corrigendum: A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection
by: Feifei Qiu, et al.
Published: (2020-07-01)

Regulatory CD4+ T cells: permanent or temporary suppressors of immunity
by: Christian LeGuern, et al.
Published: (2024-02-01)

Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4<sup>+</sup>CD25<sup>+ </sup>cells
by: Uchiyama Masateru, et al.
Published: (2012-03-01)

Intragraft regulatory T cells in the modern era: what can high-dimensional methods tell us about pathways to allograft acceptance?
by: Ke Fan Bei, et al.
Published: (2023-11-01)

Kidney allograft rejection is associated with an imbalance of B cells, regulatory T cells and differentiated CD28-CD8+ T cells: analysis of a cohort of 1095 graft biopsies
by: Hoa Le Mai, et al.
Published: (2023-04-01)

Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells
by: Mélanie Lalfer, et al.
Published: (2019-03-01)

IL-34 Actions on FOXP3+ Tregs and CD14+ Monocytes Control Human Graft Rejection
by: Séverine Bézie, et al.
Published: (2020-08-01)

Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation
by: Ilse Gille, et al.
Published: (2022-05-01)

Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report
by: Yaghoub Mollaei-Kandelous, et al.
Published: (2022-09-01)

Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival
by: Gil-Ran Kim, et al.
Published: (2024-12-01)

Regulatory T cells: serious contenders in the promise for immunological tolerance in transplantation
by: Niloufar eSafinia, et al.
Published: (2015-08-01)