<i>Lhb</i><sup>−/−</sup><i>Lhr</i><sup>−/−</sup> Double Mutant Mice Phenocopy <i>Lhb</i><sup>−/−</sup> or <i>Lhr</i><sup>−/−</sup> Single Mutants and Display Defects in Leydig Cells and Steroidogenesis

<i>Lhb</i><sup>−/−</sup><i>Lhr</i><sup>−/−</sup> Double Mutant Mice Phenocopy <i>Lhb</i><sup>−/−</sup> or <i>Lhr</i><sup>−/−</sup> Single Mutants and Display Defects in Leydig Cells and Steroidogenesis

In the mouse, two distinct populations of Leydig cells arise during testis development. Fetal Leydig cells arise from a stem cell population and produce T required for masculinization. It is debated whether they persist in the adult testis. A second adult Leydig stem cell population gives rise to pr...

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Bibliographic Details
Main Authors: Zhenghui Liu, Mark Larsen, Zhenmin Lei, C. V. Rao, T. Rajendra Kumar
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
LH
Leydig cell
LH-receptor
testosterone
spermatogenesis
thrombospondin-2
Online Access:https://www.mdpi.com/1422-0067/23/24/15725

Internet

https://www.mdpi.com/1422-0067/23/24/15725

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