mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis

mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis

A pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter accompanied by compromised remyelination. Demyelinated lesions are deeply associated with oligodendrocyte apoptosis and a robust inflammatory response. Although various studies point towards a noxious role of inf...

Full description

Bibliographic Details
Main Authors: Nathalie Laflamme, Giulia Cisbani, Paul Préfontaine, Younes Srour, Jordan Bernier, Marie-Kim St-Pierre, Marie-Ève Tremblay, Serge Rivest
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
mCSF
microglial cells
multiple sclerosis
mouse models
demyelination
remyelination
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00178/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00178/full

Similar Items