mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis
A pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter accompanied by compromised remyelination. Demyelinated lesions are deeply associated with oligodendrocyte apoptosis and a robust inflammatory response. Although various studies point towards a noxious role of inf...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00178/full |
| _version_ | 1819097543894630400 |
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| author | Nathalie Laflamme Giulia Cisbani Paul Préfontaine Younes Srour Jordan Bernier Marie-Kim St-Pierre Marie-Ève Tremblay Serge Rivest |
| author_facet | Nathalie Laflamme Giulia Cisbani Paul Préfontaine Younes Srour Jordan Bernier Marie-Kim St-Pierre Marie-Ève Tremblay Serge Rivest |
| author_sort | Nathalie Laflamme |
| collection | DOAJ |
| description | A pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter accompanied by compromised remyelination. Demyelinated lesions are deeply associated with oligodendrocyte apoptosis and a robust inflammatory response. Although various studies point towards a noxious role of inflammation in MS, others emphasize a positive role for the innate immune cells in disease progression. A cytokine well-known to stimulate cell survival, proliferation and differentiation of myeloid cells, macrophage colony-stimulating factor (mCSF), was administered to mice during a 5 week-long cuprizone diet. Treated mice exhibited reduced myelin loss during the demyelination phase, together with an increased number of microglia and oligodendrocyte precursor cells in lesion sites. Tamoxifen-induced conditional deletion of the mCSF receptor in microglia from cuprizone-fed mice caused aberrant myelin debris accumulation in the corpus callosum and reduced microglial phagocytic response. mCSF therefore plays a key role in stimulating myelin clearance by the brain innate immune cells, which is a prerequisite for proper remyelination and myelin repair processes. |
| first_indexed | 2024-12-22T00:16:46Z |
| format | Article |
| id | doaj.art-9ec84f5070ca4cf28ca060fc28505ef5 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-22T00:16:46Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-9ec84f5070ca4cf28ca060fc28505ef52022-12-21T18:45:16ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-07-011210.3389/fncel.2018.00178389692mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple SclerosisNathalie LaflammeGiulia CisbaniPaul PréfontaineYounes SrourJordan BernierMarie-Kim St-PierreMarie-Ève TremblaySerge RivestA pathological hallmark of multiple sclerosis (MS) is myelin loss in brain white matter accompanied by compromised remyelination. Demyelinated lesions are deeply associated with oligodendrocyte apoptosis and a robust inflammatory response. Although various studies point towards a noxious role of inflammation in MS, others emphasize a positive role for the innate immune cells in disease progression. A cytokine well-known to stimulate cell survival, proliferation and differentiation of myeloid cells, macrophage colony-stimulating factor (mCSF), was administered to mice during a 5 week-long cuprizone diet. Treated mice exhibited reduced myelin loss during the demyelination phase, together with an increased number of microglia and oligodendrocyte precursor cells in lesion sites. Tamoxifen-induced conditional deletion of the mCSF receptor in microglia from cuprizone-fed mice caused aberrant myelin debris accumulation in the corpus callosum and reduced microglial phagocytic response. mCSF therefore plays a key role in stimulating myelin clearance by the brain innate immune cells, which is a prerequisite for proper remyelination and myelin repair processes.https://www.frontiersin.org/article/10.3389/fncel.2018.00178/fullmCSFmicroglial cellsmultiple sclerosismouse modelsdemyelinationremyelination |
| spellingShingle | Nathalie Laflamme Giulia Cisbani Paul Préfontaine Younes Srour Jordan Bernier Marie-Kim St-Pierre Marie-Ève Tremblay Serge Rivest mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis Frontiers in Cellular Neuroscience mCSF microglial cells multiple sclerosis mouse models demyelination remyelination |
| title | mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis |
| title_full | mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis |
| title_fullStr | mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis |
| title_full_unstemmed | mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis |
| title_short | mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis |
| title_sort | mcsf induced microglial activation prevents myelin loss and promotes its repair in a mouse model of multiple sclerosis |
| topic | mCSF microglial cells multiple sclerosis mouse models demyelination remyelination |
| url | https://www.frontiersin.org/article/10.3389/fncel.2018.00178/full |
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