Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon

Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon

Abstract The design of cereblon-binding molecular glues (MGs) that selectively recruit a desired protein while excluding teratogenic SALL4 is an area of significant interest when designing therapeutic agents. Previous studies show that SALL4 is degraded in the presence of IKZF1 degraders pomalidomid...

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Bibliographic Details
Main Authors: Xiaolei Ma, Barbara Leon, Elizabeth Ornelas, Dustin Dovala, Laura Tandeske, Catherine Luu, Gwynn Pardee, Stephania Widger, Jonathan M. Solomon, Rohan E. J. Beckwith, Heinz Moser, Matthew C. Clifton, Charles A. Wartchow
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48606-3

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https://doi.org/10.1038/s41598-023-48606-3

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