Validation and interpretation of Pan-TRK immunohistochemistry: a practical approach and challenges with interpretation

Validation and interpretation of Pan-TRK immunohistochemistry: a practical approach and challenges with interpretation

Abstract Objectives Actionable, solid tumor activating neurotrophic receptor tyrosine kinase (NTRK) fusions are best detected via nucleic acid-based assays, while Pan-TRK immunohistochemistry (IHC) serves as a reasonable screening modality. We describe a practical and cost-effective approach to vali...

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Bibliographic Details
Main Authors: Cansu Karakas, Ellen J. Giampoli, Tanzy Love, David G. Hicks, Moises J. Velez
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Diagnostic Pathology
Subjects:
Pan-TRK
NTRK
Immunohistochemistry
Interpretation
Validation
Online Access:https://doi.org/10.1186/s13000-023-01426-5

Internet

https://doi.org/10.1186/s13000-023-01426-5

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