DT-0111: a novel drug-candidate for the treatment of COPD and chronic cough

Background: Extracellular adenosine 5′-triphosphate (ATP) plays important mechanistic roles in pulmonary disorders in general and chronic obstructive pulmonary disease (COPD) and cough in particular. The effects of ATP in the lungs are mediated to a large extent by P2X2/3 receptors (P2X2/3R) localiz...

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Bibliographic Details
Main Authors: Amir Pelleg, Fadi Xu, Jianguo Zhuang, Bradley Undem, Geoffrey Burnstock
Format: Article
Language:English
Published: SAGE Publishing 2019-09-01
Series:Therapeutic Advances in Respiratory Disease
Online Access:https://doi.org/10.1177/1753466619877960