Synthesis and Characterization of a Biomimetic Formulation of Clofazimine Hydrochloride Microcrystals for Parenteral Administration

Synthesis and Characterization of a Biomimetic Formulation of Clofazimine Hydrochloride Microcrystals for Parenteral Administration

Clofazimine (CFZ) is a broad spectrum antimycobacterial agent recommended by the World Health Organization as a first line treatment for leprosy and second line treatment for multidrug resistant tuberculosis. Oral administration of CFZ leads to a red skin pigmentation side effect. Since CFZ is a wea...

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Bibliographic Details
Main Authors: Mikhail D. Murashov, Jennifer Diaz-Espinosa, Vernon LaLone, Joel W. Y. Tan, Raluca Laza, Xueding Wang, Kathleen A. Stringer, Gus R. Rosania
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceutics
Subjects:
crystal-like drug inclusion (CLDI)
micronized crystals
jet milling/micronization
drug repurposing
CFZ-induced skin pigmentation
adverse drug reaction (ADR)
macrophages
Online Access:https://www.mdpi.com/1999-4923/10/4/238

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https://www.mdpi.com/1999-4923/10/4/238

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