Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression

Longitudinal single-cell analysis of a myeloma mouse model identifies subclonal molecular programs associated with progression

The molecular programs that underlie progression in multiple myeloma (MM) are incompletely understood. Here the authors use a mouse model of MM and single-cell RNA-seq to define subclonal expression programs that arise during progression and that inform targeted therapeutic strategies.

Bibliographic Details
Main Authors: Danielle C. Croucher, Laura M. Richards, Serges P. Tsofack, Daniel Waller, Zhihua Li, Ellen Nong Wei, Xian Fang Huang, Marta Chesi, P. Leif Bergsagel, Michael Sebag, Trevor J. Pugh, Suzanne Trudel
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26598-w

Internet

https://doi.org/10.1038/s41467-021-26598-w

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