A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice

A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice

Abstract Aim MC903 is a synthetic derivative of vitamin D3 that has been designed to diminish its impact on calcium metabolism and is clinically used as a transdermal reagent for psoriasis. Animal studies showed that an oral or intraperitoneal vitamin D3 treatment prevented the development of obesit...

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Bibliographic Details
Main Authors: Tsutomu Wada, Yuichiro Miyazawa, Misa Ikurumi, Kento Fuse, Akira Okekawa, Yasuhiro Onogi, Shigeru Saito, Hiroshi Tsuneki, Toshiyasu Sasaoka
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Nutrition & Metabolism
Subjects:
Calcipotriol
Myotube
Obesity
Transdermal treatment
Uncoupling protein 3 (UCP3)
Online Access:https://doi.org/10.1186/s12986-023-00732-5

Internet

https://doi.org/10.1186/s12986-023-00732-5

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