Disrupted Blood‐Brain Barrier and Mitochondrial Impairment by Autotaxin–Lysophosphatidic Acid Axis in Postischemic Stroke

Disrupted Blood‐Brain Barrier and Mitochondrial Impairment by Autotaxin–Lysophosphatidic Acid Axis in Postischemic Stroke

Background The loss of endothelial integrity increases the risk of intracerebral hemorrhage during ischemic stroke. Adjunct therapeutic targets for reperfusion in ischemic stroke are in need to prevent blood‐brain barrier disruption. Recently, we have shown that endothelial permeability is mediated...

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Bibliographic Details
Main Authors: Susmita Bhattarai, Sudha Sharma, Hosne Ara, Utsab Subedi, Grace Sun, Chun Li, Md. Shenuarin Bhuiyan, Christopher Kevil, William P. Armstrong, Miles T. Minvielle, Sumitra Miriyala, Manikandan Panchatcharam
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
autotaxin
blood‐brain barrier
ischemic stroke
lysophosphatidic acid
permeability
superoxide radicals
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.021511

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.021511

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