Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma

Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma

Abstract Background Lung adenocarcinoma (LUAD), the most common and lethal subtype of lung cancer, continues to be a major health concern worldwide. Despite advances in targeted and immune therapies, only a minority of patients derive substantial benefits. As a result, the urgent need for novel ther...

Full description

Bibliographic Details
Main Authors: Zizhen Li, Wenhua Lu, Feng Yin, Peiting Zeng, Heping Li, Amin Huang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Translational Medicine
Subjects:
LUAD
TNFSF11
GPX4
Ferroptosis
Erastin
RSL3
Online Access:https://doi.org/10.1186/s12967-024-05112-y

Internet

https://doi.org/10.1186/s12967-024-05112-y

Similar Items