Synthesis of New Purine Nucleosides as potential Metal Chelators and Anticholinesterase Agents

Synthesis of New Purine Nucleosides as potential Metal Chelators and Anticholinesterase Agents

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by multiple factors, such as the progressive decline in the levels of the neurotransmitter acetylcholine, and the deregulation of the homeostasis of bio-metals, such as copper, zinc and iron. Acetylcholine is hydrolyzed by acetylc...

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Bibliographic Details
Main Authors: Catarina Maria, João Barros, Nuno Xavier, Karina Shimizu, Adilson Freitas, Mª João Ferreira, Ignazio Schino, Mariangela Cantore, Modesto de Candia, Nicola Colabufo, José Nuno Canongia Lopes, Amélia Rauter
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Medical Sciences Forum
Subjects:
nucleosides
synthesis
cholinesterase inhibitors
metal chelation
Alzheimer’s disease
Online Access:https://www.mdpi.com/2673-9992/14/1/148

Internet

https://www.mdpi.com/2673-9992/14/1/148

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